Human Olfactory Receptor-Based Bioelectronic Nose
Tai Hyun Park, School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea
Abstract: Human has major five senses. Three of them are physical senses, which are senses of vision, hearing, and touch. The other two senses are chemical senses, which are senses of smell and taste. Science and technology for the physical senses have been advanced enormously, and electronic devices have been developed for these senses. Camera can capture the sight which we see. Audio recorder can capture the sound which we hear. Tablet PC can feel our touch. These three kinds of devices are in our smart phone. However, we do not have any device which can capture the information of smell or taste. The sense of smell has been the most mysterious sense; however, now we understand the smell sensing mechanism at the molecular level. In order to mimic the human olfactory function, we can use human olfactory receptors, which are expressed in heterologous systems such as E. coli, insect cell, and mammalian cell systems. The olfactory receptors can be combined with nanomaterials such as carbon nanotube, conducting polymer nanotube, and graphene to develop bioelectronic nose. I will present various methods for the development of bioelectronic nose using human olfactory receptors. In addition, applications and current issues of bioelectronic nose will be discussed.